UNIVERSITY OF MASSACHUSETTS;THE JACKSON LABORATORY
发明人:
BREHM, MICHAEL A.,WILES, MICHAEL V.,GREINER, DALE L.,SHULTZ, LEONARD D.
申请号：
CA3063368
公开号：
CA3063368A1
申请日:
2018.05.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A NOD.Cg-Prkdc scid H2rg tm1 Wjl /SzJ.(NOD-scid-IL2r?null, NSG) mouse which is genetically modified such that the NSG mouse lacks functional major histocompatibility complex I (MHC I) and lacks functional major histocompatibility complex II (MHC II) is provided according to aspects of the present, invention. According to specific aspects the genetically modified NSG mouse, is a NOD.Cg-Prkdc scid H2-K1 tml Bpe H2-Ab1 eml Mvw H2-D1 tml Bpe H2rg tm Wjl /SzJ (NSG-K b D b ) null (IA null )) mouse, NSG-RIP-DTR (K b D b ) null (IA null ) mouse, or a NOD.Cg-B2m tml Une PrKdc scid H2 dlAb1-E a H2rg tm1 Wjl /SzJ (NSG-B2M null (IA IE null )) mouse. Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice.
