antibodies, nucleic acid, compositions, cell, methods for preparing an antibody, to treat a subject with cancer, to treat an infectious disease, to treat an inflammation, to identify an ab, to improve an ab's anti-tumor efficacy, to improve the pharmacokinetics of an antibody, for selection of an antibody, to improve the effectiveness of antibodies, to isolate antibodies and to detect sight in a sample
BRISTOL-MYERS SQUIBB COMPANY;FIVE PRIME THERAPEUTICS, INC.
发明人:
ALAN J. KORMAN,ANDREW RANKIN,ANDY X. DENG,ARVIND RAJPAL,GINGER RAKESTRAW,KEITH SADOON BAHJAT,LIN HUI SU,LUIS BORGES,PAUL O. SHEPPARD,ROBERT J. JOHNSTON
申请号：
BR112019019108
公开号：
BR112019019108A2
申请日:
2018.03.13
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present application relates to antibodies that specifically bind to the suppressor containing immunoglobulin from domain v of t cell activation (seen) to acid ph and its use in the treatment of cancer. in some embodiments, antibodies specifically bind the human eye to acidic ph, but do not significantly bind to the human eye to neutral or physiological ph.o presente pedido se refere a anticorpos que se ligam especificamente ao supressor contendo a imunoglobulina do domínio v da ativação de células t (vista) a ph ácido e à sua utilização no tratamento de câncer. em algumas formas de realização, os anticorpos se ligam especificamente ao vista humano a ph ácido, mas não se ligam significativamente ao vista humano a ph neutro ou fisiológico.
