JI, Young-Hoon,지용훈,KIM, Dong-Hee,김동희,KIM, Jung-Ae,김정애,KANG, Jae-Seon,강재선,CHUNG, Sung-Uk,정성욱,HWANG, Sung-Woo,황성우,KANG, Kyung-Ran,강경란,KANG, You-Ra,강유라
申请号：
KRKR2011/001228
公开号：
WO2012/008674A1
申请日:
2011.02.23
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments, and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.La présente invention concerne une composition anti-angiogénique contenant des composés de macrolactine comme la macrolactine A, la 7-O-malonyl macrolactine A, et la 7-O-succinyl macrolactine A en tant qu'ingrédients actifs. Les composés de macrolactine selon la présente invention suppriment fortement l'angiogenèse dans des expériences in vivo et peuvent être utilisés comme composition pharmaceutique pour prévenir ou traiter des maladies causées par l'angiogenèse.본 발명은 마크로락틴 에이(macrolactin A), 7-O-말로닐 마크로락틴 에이(7-O-malonyl macrolactin A), 7-O-숙시닐 마크로락틴 에이(7-O-succinyl macrolactin A)와 같은 마크로락틴류 화합물들을 유효성분으로 함유하는 항혈관신생효과를 갖는 조성물에 관한 것이다. 본 발명이 제공하는 상기 마크로락틴류 화합물들은 생체내 실험에서 신생혈관형성을 강력히 억제하였으며, 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물로 사용될 수 있다.
