LOMUSCIO, STEVE,MA, HUA,MATCHETT, MICHAEL ALLEN,SANDHU, HARPREET K,SHAH, NAVNIT HARGOVINDAS,ZHANG, YU-E
申请号：
PH12015501620
公开号：
PH12015501620A1
申请日:
2015.07.22
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The invention relates to solid dispersions of poorly water soluble compounds, in particular 4-{[(2R, 3S, 4R, 5S)-4-(4-chloro-2-Fluorophenyl)-3-(3-chloro-2-Fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-pyrrolidine-2-carbonyl]amino}-3- Methoxy-Benzoic Acid, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.
