An orthosis system includes an orthotic device adapted to be worn on the hand of a subject that includes at least one brace component coupled to one or more fingers of the hand and including at least one joint permitting movement of one or more fingers. One or more actuators can be connected to each joint to cause movement of the joint. A control unit can be provided to control each of the actuators to control the movements of each joint separately. The control unit can be operated by the subject or a clinician to facilitate everyday tasks or for treatment or therapy.