FIELD: drug, drug.SUBSTANCE: invention is related to dermatology and beauty, represents a kind of pharmaceutical composition, prevents or mitigates the allergic reaction of local skin, and triethylene glycol is contained, lanthanum or cerous nitrate or chloride, glycerol, poly- ethyl glycol-115, propylene glycol, ethyl alcohol, potassium hydroxide, cedar nut oil or Silybum Marianum Gaertn Seed Oil, vitamin A, E, C, F, analgin, glyciram, morfazinamido, hyaluronic acid and distilled water, wherein ingredient draws ratio, weight %.EFFECT: product of the present invention provides extended biological skin situation improvement and protects the skin from unfavorable environmental exposure.1 TBL