Joerg Rosenberg,Gerd Woehrle,Thomas Y. Kessler,Joerg Breitenbach,Salih Durak,Friedrich W. Richter,Wei Liu,Sandeep Dutta
申请号：
US13729313
公开号：
US20130344143A1
申请日:
2012.12.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
