Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal compositions comprising peptide epoxyketone compounds, providing desirable pharmacodynamic profiles, and providing anti-tumor activity in a human tumor xenograft model, greater than or equal to non-liposomal compositions comprising peptide epoxyketone compounds. Further, experiments performed in support of the present invention demonstrated improved tolerability of liposomal compositions comprising peptide epoxyketone compounds.La présente invention concerne des compositions liposomales contenant des composés de type peptides époxycétones, ainsi que les procédés de fabrication et d'utilisation desdites compositions liposomales. Ces compositions liposomales assurent une exposition prolongée au médicament (par rapport aux compositions non liposomales contenant des composés de type peptides époxycétones) sans affecter de façon significative la biodistribution du médicament. La formulation en compositions liposomales améliore la tolérabilité des composés de type peptides époxycétones.
