ELLIS-BEHNKE RUTLEDGE,NORCHI TERRENCE W,KELLY STEPHEN RICHARD
申请号：
PL12196176
公开号：
PL2581097T3
申请日:
2008.04.25
申请国别(地区):
PL
年份:
2017
代理人:
摘要：
A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In one embodiment, the self-assembling material comprises peptides having a sequence of amino acid residues conforming to one or more of Formulas I-IV: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa neu -Xaa + ) x Xaa neu -Xaa - ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(I) €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa neu -Xaa - ) x (Xaa neu -Xaa + ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(II) €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa + -Xaa neu ) x (Xaa - -Xaa neu ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(III) €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa - -Xaa neu ) x (Xaa +- Xaa neu ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(IV), where Xaa neu represents an amino acid residue having a neutral charge； Xaa + represents an amino acid residue having a positive charge； Xaa - represents an amino acid residue having a negative charge； x and y are integers having a value of 1, 2, 3 or 4, independently； and n is an integer having a value of 1-5. In another embodiment, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
