A method for producing bone substitutes and/or fillers made to measure and made of bioactive and biomimetic materials, and to the bone substitute and/or filler obtainable with such method, comprising the steps of: - receiving clinical images of the bone defect from a clinical unit, - processing the received image in order to obtain a virtual prototype of a female mold part and male mold part of the bone defect, - converting the virtual prototype into a format which is compatible with a rapid prototyping machine, - selecting a material of which the female mold part and the male mold part are to be made, in order to provide female mold parts and male mold parts made of different materials depending on the type of production method used to obtain the bone substitute, - providing the female mold part and the male mold part by way of the rapid prototyping machine, - selecting a material of which the bone filler or substitute is to be made, - providing the bone filler or substitute.
