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NOUVEAUX VECTEURS DE BACULOVIRUS ET PROCÉDÉS D'UTILISATION
专利权人:
Reber Genetics Co.; Ltd.
发明人:
CHANG, Chia-Jung,LIAO, Yan-Chiou,CHOU, Wei-I,CHANG, Hsiu-Kang
申请号:
EP16797022
公开号:
EP3294329A4
申请日:
2016.05.13
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A recombinant baculovirus displaying on its envelop a fusion protein is disclosed. The fusion protein comprises a heterologous antigen, and a C-terminal region of baculovirus envelope GP64 protein, which has at least 100 amino acid residues in length and lacks a B12D5 binding epitope located within the central basic region of the GP64 protein. The genome of the recombinant baculovirus comprises a transgene encoding a fusion protein that comprises a signal peptide, the heterologous antigen, and the C-terminal region of the baculovirus envelope GP64 protein, in which the antigen is located between the signal peptide and the C-terminal region of the GP64 protein. Methods for eliciting an antigen-specific immunogenic response in a subject in need thereof are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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