ДУДЛЕЙ Роберт Е. (US),КОНСТАНТИНИДЕС Панайотис П. (US)
申请号：
RU2015112862
公开号：
RU2015112862A
申请日:
2015.04.08
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Oral pharmaceutical composition comprising testosterone undecanoate dissolved in a vehicle comprising at least one lipophilic surfactant, and at least one hydrophilic surfactant at a ratio of the total amount of the lipophilic surfactant to the total amount of hydrophilic surfactant (w / w), located in the range from about 6: 1 to 3.5: 1, wherein the testosterone undecanoate is dissolved from 18 to 22 wt. Kompozitsii.2%. An oral pharmaceutical composition according to claim. 1, characterized in that the at least one hydrophilic surfactant comprising Cremophor RH 40 (polyoxyethylene trigidroksistearat) .3. An oral pharmaceutical composition according to claim. 1, characterized in that at least one lipophilic surfactant comprises oleic kislotu.4. An oral pharmaceutical composition according to claim. 1, characterized in that testosterone undecanoate is dissolved in a carrier, the substantially etanola.5. An oral pharmaceutical composition according to claim. 1, characterized in that it comprises from 15 to 17 wt. % Of at least one hydrophilic PAV.6. An oral pharmaceutical composition according to claim. 1, characterized in that it comprises from 50 to 55 wt. % Of at least one lipophilic PAV.7. A method for treating testosterone deficiency or its symptoms, comprising oral administration of a patient suffering from testosterone deficiency or symptoms thereof, an effective amount of the pharmaceutical composition according to any one of claims. 1-6.8. Use of an oral pharmaceutical composition according to any one of claims. 1-6 for the manufacture of a medicament for the treatment of testosterone deficiency or simptomov.9. A method for treating testosterone deficiency or its symptoms, comprising oral administration of a patient suffering from testosterone deficiency or1. Оральная фармацевтическая композиция, содержащая тестостерона ундеканоат, растворенный в носителе, содержащем, по меньшей мере, одно липофильное ПАВ и, по меньшей мере, одно гидрофильное ПАВ при соотн
