Disclosed are compositions and methods for sustained energy and enhanced weight loss. A composition for weight loss and sustained energy in a person comprises an effective amount of one or more B vitamins and an effective amount of one or more of lysine, leucine, and methionine. The composition may further comprises an effective amount of one or more of a carbohydrate, cobalmin, and carnitine. The composition may be in a form administrable to a person orally, by intravenous infusion, or by intramuscular injection. A method of losing weight and sustaining energy comprises administering, to a person, a composition comprising an effective amount of one or more B vitamins and an effective amount of one or more of lysine, leucine, and methionine. The method may further comprise administering an effective amount of at least one of a carbohydrate, cobalmin, and carnitine.
