PROBLEM TO BE SOLVED: To provide a nucleic acid molecule for suppressing the expression of TGF-β1 gene, a composition containing the nucleic acid molecule, and uses thereof.SOLUTION: The present invention provides to a single-stranded nucleic acid molecule that suppresses the expression of the TGF-β1 gene. The single-stranded nucleic acid molecule consists of region X, linker region Lx, and region Xc. The region Lx has a non-nucleotide structure containing at least one of a pyrrolidine skeleton and a piperidine skeleton. At least one of the X and Xc comprises an expression-suppressing sequence that suppresses the expression of the TGF-β1 gene.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】TGF-β1遺伝子の発現抑制用核酸分子、前記核酸分子を含む組成物及びその用途の提供。【解決手段】TGF-β1遺伝子の発現を抑制する一本鎖核酸分子であって、領域X、リンカー領域Lx及び領域Xcのみからなり、前記Lxがピロリジン骨格およびピペリジン骨格の少なくとも一方を含む非ヌクレオチド構造を有し、かつ前記X及びXcの少なくとも一方がTGF-β1遺伝子の発現を抑制する発現抑制配列を含む、核酸分子。【選択図】図1
