OSTÉOCALCINE SOUS-CARBOXYLÉE/NON CARBOXYLÉE AUGMENTANT LA PROLIFÉRATION DES CELLULES BÊTA, LA SÉCRÉTION D'INSULINE, LA SENSIBILITÉ À L'INSULINE, LA TOLÉRANCE AU GLUCOSE ET RÉDUISANT LA MASSE GRAISSEUSE
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
申请号:
EP07838263.7
公开号:
EP2073832B1
申请日:
2007.09.13
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention relates to methods and compositions for treating and diagnosing disorders related to energy metabolism and the OST-PTP signaling pathway involving gamma-carboxylase, osteocalcin and adiponectin. Such disorders include, but are not limited to, metabolic syndrome, glucose intolerance, diabetes types 1 and 2, atherosclerosis and obesity.