MICHAEL JOHN TISDALE,HELEN LAURA ELEY,STEVE THOMAS RUSSEL,KEVIN BURKE MILLER
申请号：
BRPI0819759
公开号：
BRPI0819759A2
申请日:
2008.10.03
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to compositions and methods for preventing and treating a condition in a mammalian subject that include at least one inhibitor of double stranded RNA dependent protein kinase (PKR-I) prior to or concurrently with the treatment, wherein the treatment results to an inhibition of activation of dsRNA-dependent protein kinase. The compositions and methods of the present invention further include at least one potentiator that further enhances the inhibition of phosphorylation by PKR-I.
