The present invention is directed to twice daily sustained release pharmaceutical composition of paracetamol having an immediate release phase of paracetamol and a sustained release phase of paracetamol, said composition having unique and advantageous pharmacokinetic properties and a pharmaceutical composition comprising only a sustained release phase of paracetamol having unique and advantageous pharmacokinetic properties.本發明係關於具有對乙醯胺基酚速釋相及對乙醯胺基酚緩釋相之對乙醯胺基酚每日二次緩釋醫藥組成物,該組成物具有獨特及有利藥物動力特性,且醫藥組成物僅包含具有獨特及有利藥物動力特性之對乙醯胺基酚緩釋相。