THE UNIVERSITY OF TOKYO;SHIN NIHON SEIYAKU CO., LTD.
发明人:
Yang JIA,Shohei MIYAMOTO,Kenichiro HARA,Atsuhumi IWANAGA,Kenzaburo TANI
申请号：
US16606685
公开号：
US20200231941A1
申请日:
2018.04.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A gene-modified coxsackievirus that is to be used in oncolytic virotherapy and is improved in safety and/or aggressiveness is provided. A gene-modified coxsackievirus that contains a mutated genome with a coxsackievirus B3 wild-type (CVB3-WT) genome inserted with at least one polynucleotide constituted of a target sequence for at least one of either of miR-34a and miR-34c and is suppressed in proliferation in normal cells is provided.
