ABATE, AGNESE,CIRO MERCURIO,CARENZI, GIACOMO,MINUCCI, SAVERIO,THALER, FLORIAN,VARASI, MARIO
申请号：
BRPI0910871
公开号：
BRPI0910871A2
申请日:
2009.04.14
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: the dotted line is an optional additional bond； n is zero or an integer from 1 to 4； R 1 is hydrogen； C 1 -C 6 alkyl, optionally substituted by aryl or by heteroaryl； (CO) R 3 ； (SO 2 ) R 4 ； aryl； or heteroaryl； R 2 is C 1 -C 6 alkyl, optionally substituted by aryl or by heteroaryl； aryl； heteroaryl； or (CO) R 5 ； X is CH 2 , oxygen or N R 6 ； Y is a bond, CH R 7 or N R 8 ； Z is oxygen, C R 9 R 10 or C= R 11 ； and R 3 , R 4 , R 5 , R 6 , R 3 R 8 , R 9 , R 10 and R 11 are as further defined in the specification； and pharmaceutical acceptable salts thereof.
