ШИ Рувэн (US),ХЬЮЗ Патрик М. (US),БЕРК Джеймс Эй. (US),РОБИНСОН Майкл Р. (US),ЛЮ Хуй (US)
申请号：
RU2012146630/15
公开号：
RU2012146630A
申请日:
2011.04.05
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Slow-release implant for intraocular use for treating increased intraocular pressure, configured for intra-chamber or anterior vitreal administration to a patient with increased intraocular pressure (IOP), comprising a core of antihypertensive substance surrounded by a polymer that limits the rate of passage of the antihypertensive substance from the implant into the eye of the specified the patient and the aforementioned implant provides a linear release rate of therapeutically effective The number of said antihypertensive agent into the eye for a period of time ranging from about 12 days to 365 dney.2. An implant according to claim 1, characterized in that said polymer is a non-biodegradable polymer. The implant according to claim 2, characterized in that the aforementioned polymer is selected from the group consisting of silicone elastomers, poly (ethylene-co-vinyl acetate) and polyurethane. An implant according to claim 1, characterized in that said polymer is a biodegradable polymer. The implant according to claim 4, characterized in that said polymer is an aliphatic polyester. The implant according to claim 1, characterized in that the antihypertensive substance is selected from the group consisting of antihypertensive lipids, beta-adrenergic receptor antagonists, alpha-adrenergic agonists, sympathomimetics, narrowing pupils, carbonic anhydrase inhibitors, Rho kinase inhibitors, calcium blockers , vaptans (vasopressin receptor antagonists) and cannabinoids. 7. The implant according to claim 6, characterized in that the antihypertensive substance is selected from the group consisting of and1. Имплантат замедленного высвобождения для внутриглазного использования для лечения повышенного внутриглазного давления, сконфигурированный для внутри камерного или переднего витреального введения пациенту с повышенным внутриглазным давлением (ВГД), содержащий ядро антигипертензивного вещества, окруженное полимером, который ограничивает скорость прохождения антигипертензи
