The present invention provides methods for treating or ameliorating primary progressive multiple sclerosis (PPMS) or secondary progressive multiple sclerosis (SPMS) and related symptoms by administering or implanting a depot formulation comprising glatiramer salts, such as glatiramer acetate (GA).La presente invencion proporciona metodos para tratar o aliviar la esclerosis multiple primaria progresiva (EMPP) o la esclerosis multiple secundaria progresiva (EMPS) y síntomas relacionados administrando o implantando una formulacion de deposito que comprende sales de glatiramer, tal como acetato de glatiramer (GA).