The invention provides for a method of obtaining a composite 3D ultrasound image of a region of interest. The method includes obtaining preliminary ultrasound data from a region of interest of a subject and identifying an anatomical feature within the region of interest based on the preliminary ultrasound data. A first imaging position and one or more additional imaging positions are then determined based on the anatomical feature. A first 3D ultrasound image is obtained from the first imaging position and one or more additional 3D ultrasound images are obtained from the one or more additional imaging positions, wherein a portion of the first 3D ultrasound image overlaps a portion of the one or more additional 3D ultrasound images, thereby forming an overlapping portion comprising the anatomical feature. Spatial registration is performed between the first 3D ultrasound image and the one or more additional 3D ultrasound images based on the anatomical feature the 3D ultrasound images are then blended based on the spatial registration, thereby generating a composite 3D ultrasound image.
