A compound represented by the formula (1) or a salt thereof (X is a carbonyl, having mPGES-1 inhibitory activity and useful as an active ingredient of a medicament for the prevention and / or treatment of diseases such as inflammation, pain, or rheumatism R 1 is a hydrogen atom, a halogen atom, an alkyl group, an alkanoyl group, a cyano group or a carboxyl group; R 2 is an alkyl group, a carbocyclic group or a heterocyclic group; R 3 is a hydrogen atom or 1 to Three substituents; R 4 and R 5 each represents a hydrogen atom, a halogen atom, or an alkyl group; R 6 represents an alkyl group or an alkoxy group);mPGES-1阻害作用を有し、炎症、疼痛、又はリウマチなどの疾患の予防及び/又は治療のための医薬の有効成分として有用な式(1)で表される化合物又はその塩(Xはカルボニル基又はスルホニル基;R1は水素原子、ハロゲン原子、アルキル基、アルカノイル基、シアノ基、又はカルボキシル基;R2はアルキル基、炭素環基、又は複素環基;R3は水素原子又は1ないし3個の置換基;R4及びR5は水素原子、ハロゲン原子、又はアルキル基;R6はアルキル基、又はアルコキシ基を示す)。