針對CLDN18.2和CD3之抗體構建體农业专利-农业学术服务平台

发明人:: DAHLHOFF, CHRISTOPH,戴尔哈福　克里斯多福,戴爾哈福　克里斯多福,BLUEMEL, CLAUDIA,布鲁梅尔　克劳蒂亚,布魯梅爾　克勞蒂亞,BROZY, JOHANNES,波西　乔汉斯,波西　喬漢斯,RAUM, TOBIAS,瑞乌　托拜耳斯,瑞烏　托拜耳斯,NAHRWOLD, ELISABETH,那尔沃德　伊丽莎贝斯,那爾沃德　伊麗莎貝斯,ARVEDSON, TARA,亚维德森

摘要：: The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.本發明係關於抗體構建體，該抗體構建體包含結合緊密連接蛋白18.2（CLDN18.2）的結構域和結合CD3的另一個結構域。此外，本發明提供了編碼該抗體構建體的多核苷酸、包含所述多核苷酸的載體、以及用所述多核苷酸或載體轉化或轉染的宿主細胞。此外，本發明提供了用於產生本發明的抗體構建體的方法、所述抗體構建體的醫學用途、以及包含所述抗體構建體的套組。