An exemplary method for optimizing pacing configuration includes providing distances between electrodes of a series of three or more ventricular electrodes associated with a ventricle； selecting a ventricular electrode from the series； delivering energy to the ventricle via the selected ventricular electrode, the energy sufficient to cause an evoked response； acquiring signals of cardiac electrical activity associated with the evoked response via non-selected ventricular electrodes of the series； based on signals of cardiac electrical activity acquired via the non-selected ventricular electrodes and the distances, determining conduction velocities； based on the conduction velocities, deciding if the selected ventricular electrode is an optimal electrode for delivery of a cardiac pacing therapy； and, if the selected ventricular electrode comprises an optimal electrode for delivery of the cardiac pacing therapy, calling for delivery of the cardiac pacing therapy using the selected ventricular electrode. Various other methods, devices, systems, etc., are also disclosed.
