viral, cloning or expression vector, transgenic microorganism, pharmaceutical composition, kit for detecting an htrt polynucleotide or fragment thereof, uses of a polynucleotide, a peptide, a transgenic microorganism and a vector, and methods for obtaining a htrt recombinant peptide, to inhibit htrt expression, to increase the replicative ability of a cell, to detect an htrt polynucleotide or fragment thereof, to evaluate a condition associated with altered htrt expression, to express a heterologous gene, to selectively extinguish a trt-expressing cell, and to map a test compound for an abilit
GERON CORPORATION;THE REGENTS OF THE UNIVERSITY OF COLORADO;University License Equity Holdings, Inc.;University Technology
发明人:
Calvin B. Harley,Gregg B. Morin,Joachim Lingner,Karen B. Chapman,Thomas R. Cech,Toru Nakamura,William H. Andrews
申请号：
BRPI9712254
公开号：
BRPI9712254B1
申请日:
1997.10.01
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
htrt isolated protein preparation, htrt protein fragment, human telomerase, isolated polynucleotide, expression vector, cell, non-human organism, isolated or recombinant antibody, processes for determining whether a compound or treatment is a modulator of an activity or expression If a test compound is a modulator of a telomerase reverse transcriptase activity, to identify a compound that modulates htrt activity, to prepare recombinant telomerase, to detect a product of htrt people in a sample and the presence of at least one positive human telomerase cell in a biological sample, to diagnose a telomerase-related condition in a cancer patient and to provide a prognosis for a cancer patient, to monitor the ability of an anti-cancer treatment, to reduce proliferative capacity. cancer cells in a patient to increase the proliferative capacity of a woman. vertebrate cell, to treat a condition associated with a high level of telomerase activity within a cell, to isolate selected nucleic acid of unknown sequence, to detect an htrt gene product in a sample and the presence of at least one cell positive human telomerase in a biological sample, kit for detecting a htrt gene or gene product, pharmaceutical and pharmaceutical compositions, vaccine, isolated htrp protein, uses of a polynucleotide, antibody, and an expression enhancer of htrt, protein, variant or fragment, and use of a protein, polypeptide or fragment and use thereof ". The invention provides compositions and processes related to human telomerase reverse transcriptase (htrt), the catalytic subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for the diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for the identification and screening of compounds and treatments useful for treating diseases such as cancers.preparação proteínica isolada e de htrt, fragmento de proteína de htrt, telomerase humana, polinuc
