MACDONALD LYNN,TU NAXIN,GURER CAGAN,STEVENS SEAN,MURPHY ANDREW J
申请号：
IN6233/CHENP/2012
公开号：
IN2012CN06233A
申请日:
2012.07.16
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Genetically modified non human animals and methods and compositions for making and using them are provided wherein the genetic modification comprises a deletion of the endogenous low affinity Fc?R locus and wherein the mouse is capable of expressing a functional FcR? chain. Genetically modified mice are described including mice that express low affinity human Fc?R genes from the endogenous Fc?R locus and wherein the mice comprise a functional FcR? chain. Genetically modified mice that express up to five low affinity human Fc?R genes on accessory cells of the host immune system are provided.
