Ramon Mangues Bafalluy,Isolda Casanova Rigalt,Fernando Albericio Palomera,Mercedes Álvarez,Svetlana Savina
申请号：
US13387634
公开号：
US20120196915A1
申请日:
2010.07.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a new series of 1,2-diphenylpyrroles of formula (I) or their pharmaceutically acceptable salts, or their pharmaceutically acceptable solvates, having antitumor activity, wherein R1 and R2 are individually selected from the group consisting of halogen, optionally substituted O(C1-C4)alkyl and optionally substituted (C1-C4)alkyl and R3 is selected from the group consisting of H, (C1-C4)alkyl, CONH2 and (C═NH)NH2. It also relates to a process for preparing them, to pharmaceutical compositions containing them, and to their use for the treatment of cancer, in particular lung carcinoma, colorectal carcinoma, breast carcinoma and/or prostate carcinoma.
