Andreas Mitsch,Karl-Hermann Schlingensiepen,Bernd Betzler,Frank Jaschinski,Anneliese Schneider
申请号：
US13703260
公开号：
US20130172238A1
申请日:
2011.06.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5′-end or the 3′-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5′-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder.
