您的位置: 首页 > 农业专利 > 详情页

COMPOSÉS DE DIOXYDE DE THIADIAZINE SUBSTITUÉE TRICYCLIQUE UTILISÉS EN TANT QU'INHIBITEURS DE BACE, COMPOSITIONS ET LEUR UTILISATION
专利权人:
Merck Sharp & Dohme Corp.
发明人:
申请号:
EP13846341.9
公开号:
EP2908824B1
申请日:
2013.10.14
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): (I) and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, wherein the middle ring (referred to herein as “ring B”) of the tricyclic substituent is an optionally substituted 6-membered ring, and each of the remaining variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充