#$%^&*AU2016266076A120161222.pdf#####H:\rr\Introvn\NRPortbl\DCC\RR\6092742_I.DOC-13/03/2014 ABSTRACT The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate nociceptive signaling in a cell or prevent and/or treat pain in a patient.