Conventionally, respiratory assistance device applied to Auto CPAP respiratory therapy or the like includes a long air tube which supplies pressurized air thus being difficult to handle, and there is a problem in that the degree of freedom of the head is restricted thus interrupting sleep. The present invention provides a respiratory assistance device suitable for Auto CPAP respiratory therapy. The respiratory assistance device includes: a blower device including a blower configured to generate pressurized air； an operation device including an operation interface configured to control the blower； wireless or wired communication means configured to connect the blower device and the operation device to each other； an attachment part configured to be attached to a head of a patient so as to supply the pressurized air to an airway of the patient； and an air tube through which the pressurized air is introduced into the attachment part from the blower device, wherein the blower device is accommodated in a blower device casing, and the operation device is accommodated in an operation device casing separate from the blower device casing.
