Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and use as kinase inhibitors

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专利权人:

Nerviano Medical Sciences S.r.l.

发明人:

MARCHIONNI, Chiara,ZUCCOTTO, Fabio,BADARI, Alessandra,ANGIOLINI, Mauro,CARENZI, Davide,CALDARELLI, Marina,PULICI, Maurizio

申请号：

ES10725144

公开号：

ES2570756T3

申请日:

2010.06.11

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

Compound of formula (I) ** Formula ** where R1 is hydrogen； ** Formula ** R2 is R2 ', where R2' is； R3 is NH2, where L2 is CH2CH2, CH>； = CH or C≡C； A is a direct link, O, OCH2, OCO, CON (Y), CON (Y) OR, CON (Y) N (Y), CON (Y) SO2, N (Y), N (Y) CO, N (Y) SO2-, N (Y) WITH (Y), N (Y) CSN (Y), N (Y) WITH (Y) N (Y), N (Y) COO, N (Y) WITH (Y ) SO2 or N (Y) SO2N (Y)； Y is hydrogen or an optionally substituted linear or branched (C1-C3) alkyl； R5 is hydrogen or an optionally substituted group selected from linear or branched (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl； R6 is selected from hydrogen, halogen, trifluoromethyl, (C1-C3) alkyl and (C1-C3) alkoxy； R4 an optionally substituted group selected from linear or branched (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C6) cycloalkyl and heterocyclyl； and pharmaceutically acceptable salts.Compuesto de fórmula (I)**Fórmula** donde R1 es hidrógeno；**Fórmula** R2 es R2', donde R2' es ； R3 es NH2, donde L2 es CH2CH2, CH>；=CH o C≡C； A es un enlace directo, O, OCH2, OCO, CON(Y), CON(Y)O, CON(Y)N(Y),CON(Y)SO2, N(Y), N(Y)CO, N(Y)SO2-, N(Y)CON(Y), N(Y)CSN(Y), N(Y)CON(Y)N(Y), N(Y)COO, N(Y)CON(Y)SO2 o N(Y)SO2N(Y)； Y es hidrógeno o un alquilo (C1-C3) lineal o ramificado opcionalmente sustituido； R5 es hidrógeno o un grupo opcionalmente sustituido seleccionado entre alquilo (C1-C8) lineal o ramificado, alquenilo (C2-C8), alquinilo (C2-C8), cicloalquilo (C3-C8), heterociclilo, arilo y heteroarilo； R6 se selecciona entre hidrógeno, halógeno, trifluorometilo, alquilo (C1-C3) y alcoxi (C1-C3)； R4 un grupo opcionalmente sustituido seleccionado entre alquilo (C1-C6) lineal o ramificado, alquenilo (C2-C6), alquinilo (C2-C6), cicloalquilo (C3-C6) y heterociclilo； y sales farmacéuticamente aceptables.

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