domain antibody monomer, ligand, isolated and recombinant nucleic acids, vector, host cell, method for producing a ligand dab monomer, pharmaceutical composition, drug delivery device, use of a domain antibody monomer, and, method to treat an inflammatory disease, arthritis or respiratory disease
Amrik Basran,Ian M. Tomlinson,Philip D. Drew,Rudolf M. T. de Wildt
申请号：
BRPI0619225
公开号：
BRPI0619225A2
申请日:
2006.11.30
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention relates to dAb monomers that bind IL-1R1 and inhibit binding of IL-1 (e.g., IL-1alpha and/or IL-1beta) to the receptor but do not inhibit binding of IL-1ra to IL-1R1, and to ligands comprising such dAb monomers. The invention relates to protease resistand dAb monomers, and to ligands comprising protease resistant dAb monomers. The invention also relates to nucleic acids including vectors that encode the dAb monomers and ligand, to host cells that comprise the nucleic acids and to method for producing a dAb monomer or ligand. The invention also relates to pharmaceutical compositions that comprise the dAb monomers or ligands, and to therapeutic methods that comprise administering a dAb monomer of ligand.
