Lucy RUTTEN,Daphné TRUAN,Nika Mindy STROKAPPE,Johannes Petrus Maria LANGEDIJK
申请号：
US15704651
公开号：
US20180072777A1
申请日:
2017.09.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins have certain amino acid substitutions at specified positions in the envelope protein sequence. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to an HIV envelope protein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, nucleic acid, and vectors.
