The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.本發明係關於一種抑制RRM2基因表現之雙股核糖核酸(dsRNA)。本發明亦關於一種醫藥組合物,其包含該dsRNA或編碼其之核酸分子或載體以及醫藥學上可接受之載劑;使用該醫藥組合物治療RRM2基因表現所引起之疾病的方法;及抑制細胞表現RRM2之方法。