The present application provides immune cells comprising an HPV antigen and an adjuvant, methods of manufacturing such modified immune cells, and methods of using such modified immune cells for treating an HPV-associated disease, preventing an HPV-associated disease and/or for modulating an immune response in an individual with an HPV-associated disease.本申請案提供包含HPV抗原和佐劑之免疫細胞、製造此等經修飾之免疫細胞的方法、和使用此等經修飾之免疫細胞以用於治療HPV相關疾病、預防HPV相關疾病和/或用於調節患有HPV相關疾病之個體的免疫反應之方法。