The especially medicine active ingredient the nuclear grain for the formulation which can be discharged relatively in large quantities with specified timing is offered. As for this invention, being the nuclear grain in order to form the coat which includes the medicine active ingredient on the surface, (1) as for the aforementioned nuclear grain, it includes the inorganic material and the decay promotion component which are allowed pharmacy, (2) the aforementioned inorganic material it is poor solubility vis-a-vis the water, (3) content of the aforementioned inorganic material is 50 - 95 weight %, (4) bulk density of the aforementioned nuclear grain is above 0.6g/mL,It relates to the decay die nuclear grain for the formulation which features thing.特に医薬有効成分を所定のタイミングで比較的大量に放出できる製剤用核粒子を提供する。本発明は、医薬有効成分を含む被膜を表面に形成するための核粒子であって、(1)前記核粒子は、薬学的に許容される無機材料及び崩壊促進成分を含み、(2)前記無機材料が水に対して難溶性であり、(3)前記無機材料の含有量が50~95重量%であり、(4)前記核粒子の嵩密度が0.6g/mL以上である、ことを特徴とする製剤用崩壊型核粒子に係る。
