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EXTRACELLULAR MATRIX COMPOSITIONS FOR CANCER TREATMENT
专利权人:
ИНК. (US);ХИСТОДЖЕН
发明人:
НОТОН Гейл К. (US),ПИННИ Эмметт (US)
申请号:
RU2011123788/15
公开号:
RU2011123788A
申请日:
2009.01.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of inhibiting the growth or proliferation of cancer cells, comprising contacting the cancer cell with an extracellular matrix composition. The method of claim 1, wherein the cancer cell originates from a tumor. The method of claim 1, wherein the cancer cell is derived from a cancer selected from the group consisting of melanoma, glioma and adenocarcinoma. The method according to claim 1, wherein the extracellular matrix composition is obtained from cultured cells on a two- or three-dimensional surface in a suitable growth medium. The method of claim 4, wherein the cells are derived from adult tissues, fetal or embryonic tissues. The method of claim 4, wherein the cells are cultured under hypoxic conditions. The method of claim 6, wherein the hypoxic oxygen conditions are 1-5% oxygen. The method of claim 1, wherein the composition is a soluble fraction. The method of claim 1, wherein the composition is an insoluble fraction. The method according to claim 1, wherein the composition is a combination of a soluble and insoluble fraction. The method of claim 8, wherein the soluble fraction comprises a molecular fraction including molecules having a molecular weight of less than 30,000 Da. The method of claim 1, wherein the extracellular matrix composition comprises a chemotherapeutic agent. The method of claim 12, wherein the chemotherapeutic agent is cisplatin. The method of claim 12, wherein the extracellular matrix composition further comprises an immunomodulatory agent. A method for delivering a chemotherapeutic agent to a cancer cell, comprising contacting the cancer cell with an extracellular matrix composition comprising chemo�1. Способ ингибирования роста или пролиферации раковых клеток, включающий контактирование раковой клетки с композицией внеклеточного матрикса.2. Способ по п.1, в котором раковая клетка происходит из опухоли.3. Способ по п.1, в котором раковая клетка происходит из рака, выбранного из группы, состоящей из меланомы, глиомы и аденокар
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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