This publication introduces compounds, their composition and use. 1. Claim 1: a formula compound (1),Or a pharmaceutically acceptable salt, where the A-ring is selected from a 3-8-member saturated or partially unsaturated monocyclic cyclic carbon ring, phenyl, an 8-10 member carbon ring with bicyclic aromatics, A partially unsaturated monocyclic ring consisting of four to eight members, one to two heteroatoms independently selected from nitrogen, oxygen or sulfur, combined with aromatic rings of five to six members, with 0 to four heteroatoms independently selected from nitrogen, oxygen or sulfur,A partially unsaturated, aperiodic spiral ring of 7 to 12 members, consisting of 1 to 2 non atoms, selected independently from nitrogen, oxygen or sulfur； a partially unsaturated aperiodic double ring of 7 to 12 members, consisting of 1 to 4 members, independently selected from nitrogen, oxygen or sulfur； and； A semi unsaturated bicyclic aperiodic bridge ring of 7 to 12 members, consisting of 1 to 2 heteroatoms independently selected from nitrogen, oxygen or sulfur, and a monocyclic heteroaromatic ring of 5 to 6 members, consisting of 1 to 4 heteroatoms selected from nitrogen, oxygen or sulfur,A bicyclic aromatic ring composed of 8 to 10 members, which is independently selected from nitrogen, oxygen or sulfur by 1 to 5 heteroatoms； or het, where het is a saturated single ring composed of 4 to 8 members, and 1 to 2 heteromorphic atoms are independently selected from nitrogen, oxygen or sulfur, A saturated aperiodic spiral ring of 7 to 12 members, consisting of 1 to 4 heteroatoms independently selected from nitrogen, oxygen or sulfur, and a saturated aperiodic double ring of 7 to 12 members, consisting of 1 to 3 heteroatoms independently selected from nitrogen,Oxygen or sulfur, or a saturated bicyclic heterocyclic ring, a bridge of 7 to 12 members, consisting of 1-2 non atoms, selected independently from nitrogen, oxygen or sulfur； ring B is a compound selected from the formu
