Problem to be solved: to convert cells capable of forming epithelium epithelium formation ability directly from somatic cells.Problem to be solved: to provide a method of producing a cell having a superficial epithelium organization forming ability including the step of introducing at least one gene which is strongly expressed to a cell having the ability to form a superficial epithelial tissue into a somatic cell.No selection【課題】身体外皮として働きうる重層上皮組織形成能を有する細胞を体細胞から直接転換させること。【解決手段】重層上皮組織形成能を有する細胞に相対的に強発現する少なくとも1種の遺伝子を体細胞に導入する工程を含む、重層上皮組織形成能を有する細胞の製造方法。【選択図】なし