The present invention relates to combinations between artemisinin-based potent anti-malarial agents, selected from the group consisting of ART, DHA and ARM, and a further chemotherapeutic drug selected from the group consisting of a camptothecin derivative, or a PARP-1 inhibitor, or an intercalating DNA agent, or an alkylating agent. Such combinations, showed medium to strong synergism in various models of cancer, in particular in NSCL.本發明關於選自ART、DHA及ARM所組成之群組的青蒿素基有效抗瘧疾劑與選自喜樹鹼衍生物、或PARP-1抑制劑、或DNA嵌入劑或烷化劑所組成之群組的另一化學治療劑之間的組合物。這類組合物在各種癌症模型中(尤其是在NSCL中)顯示出中等至強勁的協同作用。