FINLEY, DANIEL,KING, RANDALL, W.,LEE, BYUNG-HOON,LEE, MIN, JAE,GAHMAN, TIMOTHY, C.
申请号：
EP11810459
公开号：
EP2595993A4
申请日:
2011.07.22
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
