Cosmetic treatment for improving and/or protecting the dermal-epidermal junction (DEJ) of the skin, scalp and mucosa comprises topical application of a composition containing at least one agent (I) that modulates plectin/HD1, entactin/nidogen and/or perlecan. An Independent claim is also included for a cosmetic composition containing at least one (I), also UV protecting agents and/or antioxidants.
