The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.本發明提供式1化合物, 及其立體異構物、醫藥上可接受的鹽、及衍生物;及製造及使用此等化合物之方法。本發明包括含有此等化合物之醫藥組成物,及此等化合物在治療症狀、疾病、或病症之方法中之用途。