The present invention relates to novel compounds from the class of azalide antibiotics. Particularly the invention relates to novel 3-descladinosyl-0-carbamoyl-9-deoxo-9a-aza- 9a-homoerythromycin compounds and to their pharmaceutically acceptable derivatives. The present invention also relates to the use of such compounds as anti-microbial agents, to pharmaceutical compositions comprising such compounds, as well as to methods of manufacturing such compounds.La présente invention concerne de nouveaux composés de la classe des antibiotiques azalides. En particulier, linvention concerne de nouveaux composés 3-descladinosyl-O-carbamoyl-9-désoxo-9a-aza-9a-homoérythromycines et leurs dérivés pharmaceutiquement acceptables. La présente invention concerne également lutilisation de ces composés en tant quagents antimicrobiens, des compositions pharmaceutiques comprenant ces composés ainsi que des procédés de fabrication de ces composés.