Herein disclosed is and use anti-VEGF specific antagonists to treat method benign, cancer tumor preceding or non-metastatic.Also disclose and used that the treatment of anti-VEGF specific antagonists is in that development is benign, the curees of tumor risk before the cancer or non-metastatic method.The application in new auxiliary and auxiliary cancer therapy of the method for using treatment of anti-VEGF specific antagonists or prophylaxis of tumours recurrence and VEGF specific antagonists is also disclosed.