THERAPEUTIC AGENT AND INSPECTION METHOD FOR DISEASES CAUSED BY NEUTROPHIL ACTIVATION

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专利权人:

OKAYAMA UNIV;国立大学法人 岡山大学

发明人:

NISHIBORI MASAHIRO,西堀 正洋,MORI HIDEJI,森 秀治,WAKE HIDENORI,和氣 秀徳,TAKAHASHI HIDEO,高橋 英夫,LIU KEYUE,劉 克約,TESHIGAHARA TADASHI,勅使川原 匡,SAKAGUCHI MASAKIYO,阪口 政清

申请号：

JP2015172691

公开号：

JP2016053022A

申请日:

2015.09.02

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases caused by neutrophil activation, the therapeutic agent containing a neutrophil activation regulatory agent which has a neutrophil activation controlling function and a neutrophil activation regulating function； and also to provide an inspection method for diseases caused by neutrophil activation.SOLUTION: The invention provides a therapeutic agent for inflammatory diseases associated with neutrophil activation the therapeutic agent using a neutrophil activation regulatory agent containing a histidine rich glycoprotein (HRG) as an active ingredient, and a neutrophil-endothelial cell interaction inhibitor containing the HRG as an active ingredient； and an inspection method for inflammatory diseases associated with neutrophil activation by measuring the amount of HRG in blood.SELECTED DRAWING: Figure 13【課題】好中球活性化の制御機能を有し、好中球活性化調節する機能を有する、好中球活性化調節剤を含む好中球活性化に起因する疾患の治療薬、更に好中球活性化に起因する疾患の検査方法の提供。【解決手段】ヒスチジンリッチ糖タンパク質（HRG）を有効成分とする好中球活性化調節剤、及び該HRGを有効成分とする好中球‐血管内皮細胞相互作用抑制剤とする好中球活性化に伴う炎症疾患の治療薬。更に、血中HRG量を測定することによる好中球活性化を伴う炎症性疾患の検査方法。【選択図】図１３

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中国工程科技知识中心

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