Compounds derived from phenyl etinilo, modulators of the activity of the receptor mGluR5； Preparation Process； Pharmaceutical Composition and use in the treatment of anxiety, Pain, depression, among others.
The present invention relates to ethynyl derivatives of formula I wherein Y is N or CH R1 is fluoro or chloro R2 is hydrogen or methyl or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).<；p>；COMPUESTOS DERIVADOS DE MORFOLIN-4-IL-5-3-CLOROFLUOR-FENILETINIL-PIRIMIDIN-2-IL-METANONA, ANTAGONISTAS DE RECEPTORES METABOTRÓ；PICOS DE GLUTAMATO ESPECIALMENTE DE MGLUR5 PROCEDIMIENTO DE PREPARACIÓ；N COMPOSICIÓ；N FARMACÉ；UTICA Y USO EN EL TRATAMIENTO DE ENFERMEDADES COGNITIVAS, ESQUIZOFRENIA Y OTRAS.<；/p>；
