FORMULATION DE PARVOVIRUS PERMETTANT DE TRAITER DES TUMEURS

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专利权人:

DEUTSCHES KREBSFORSCHUNGSZENTRUM;RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG

发明人:

LEUCHS, BARBARA,GELETNEKY, KARSTEN,ROMMELAERE, JEAN,DINSART, CHRISTIANE,DAHM, MICHAEL,KREBS, OTTHEINZ

申请号：

CA2990749

公开号：

CA2990749A1

申请日:

2016.05.03

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Described is a parvovirus formulation which comprises (a) at least 1 x 109 pfu/ml of parvovirus H1 (H-1PV) or a related rodent parvovirus selected from the group consisting of LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus or Rat virus (RV) and (b) a pharmaceutically acceptable carrier containing 40-50% Iodixanol (w/v), 0.7-0.9 mmol CaCl2 x 2 H2O, 50-60 mmol NaC1, 0.9-1.2 mmol KC1, 0.7-0.95 mg/ml Tromethamine and 0.05-0.15 mg/ml Edetate calcium disodium.. A preferred use is the therapy of a brain tumour by intratumoral injection.

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